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Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles. Importance of avoiding use of vardenafil if concurrently taking riociguat, a guanylate cyclase stimulator, because of the risk of potentiation of hypotensive effects.

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Vasodilating agent; a selective phosphodiesterase PDE inhibitor. North Chicago, IL; Jul. AC 19 Color: Although less affinity than sildenafil for PDE type 6 receptor in the retina, some transient visual abnormalities observed.

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Position paper: Terminal half-life 4—5 hours for drug and major metabolite. Importance of informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.